TSR1, 20S rRNA Accumulation (TSR1)

RT-PCR ELISA detected very high expression in all specific adult brain regions examined. Intermediate expression was detected in heart, whole adult brain, liver, skeletal muscle, kidney, testis, ovary, and spinal cord, and in fetal brain and liver. Little to no expression was detected in pancreas and spleen.

Tsr1, encodes a 788-amino acid protein with an N-terminal and C-terminal domain separated by a central acidic domain. The tripartite organization shares similarity to Bms1, but Tsr1 lacks the P-loop required for GTP binding and an obvious nuclear localization signal.Tsr1 is required for assembly of a transport- or maturation-competent particle or is specifically required for transport of 43S pre-ribosomal particles, but not 60S ribosome precursors, from the nucleus to the cytosol.