TYRO3 Protein Tyrosine Kinase (TYRO3)
BYK; Brt; Dtk; RSE; Sky; Tif
Loss of function of the 3 TAM receptors, Tyro3, Axl, and Mer (MERTK), results in profound dysregulation of the immune response in mice (see ANIMAL MODEL). By analyzing TAM function in the dendritic cell subset of mouse antigen-presenting cells, Rothlin et al. (2007) found that TAM inhibited inflammation through an essential stimulator of inflammation, Ifnar, and its associated transcription factor, Stat1. Toll-like receptor (TLR) induction of Ifnar-Stat1 signaling upregulated the TAM system, which, in turn, induced the cytokine and TLR suppressors Socs1 and Socs3. Rothlin et al. (2007) concluded that cytokine-dependent activation of TAM signaling diverts a proinflammatory pathway to provide an instrinsic feedback inhibitor of both TLR- and cytokine-driven immune responses.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant TYRO3 Protein Tyrosine Kinase (TYRO3) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to TYRO3 Protein Tyrosine Kinase (TYRO3) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to TYRO3 Protein Tyrosine Kinase (TYRO3) Polyclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant TYRO3 Protein Tyrosine Kinase (TYRO3) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to TYRO3 Protein Tyrosine Kinase (TYRO3) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to TYRO3 Protein Tyrosine Kinase (TYRO3) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for TYRO3 Protein Tyrosine Kinase (TYRO3) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for TYRO3 Protein Tyrosine Kinase (TYRO3) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant TYRO3 Protein Tyrosine Kinase (TYRO3) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to TYRO3 Protein Tyrosine Kinase (TYRO3) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to TYRO3 Protein Tyrosine Kinase (TYRO3) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for TYRO3 Protein Tyrosine Kinase (TYRO3) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for TYRO3 Protein Tyrosine Kinase (TYRO3) ELISA Kit Customized Service Offer