Talanin (TALN)

ZNF365 encodes at least 4 deduced protein isoforms of 407, 333, 462, and 216 amino acids, designated ZNF365A-D, respectively. Northern blot analysis revealed ubiquitous expression of a 5-kb ZNF36A transcript but no signal for the other isoforms. By RT-PCR analysis, ZNF365A was expressed at high levels in brain and at low levels in other tissues; ZNF365B is expressed in placenta and at low levels in lung and liver; ZNF365C is expressed only in kidney and pancreas; and ZNF365D is expressed in placenta, lung, liver, kidney, and pancreas. The deduced protein contains 407 amino acids. RT-PCR ELISA detected high expression in brain and intermediate to low expression in heart, lung, skeletal muscle, kidney, pancreas, spleen, testis, and ovary. Little to no expression was detected in liver.