Target Of Myb1 Like Protein 1 (TOM1L1)

The N-terminal domain of TOM1 shares sequence similarity with the N-terminal domains of human HGS , human STAM, and yeast VPS27, all of which are proteins associated with vesicular trafficking at the endosome.

By searching sequence databases using TOM1 as the query, Seroussi et al. (1999) identified TOM1L1 as another protein with an N-terminal domain similar to that of TOM1. The authors assembled the sequences of a group of human TOM1L1 ESTs into a contiguous cDNA encoding a deduced 476-amino acid protein. TOM1L1 shares 37% sequence identity with TOM1; its C-terminal domain is not similar to that of TOM1.