Target Of Myb Protein 1 (TOM1)

The deduced 492-amino acid TOM1 protein has an N-terminal domain that shares sequence similarity to the N-terminal domains of human HGS, human STAM, and yeast VPS27, all of which are proteins associated with vesicular trafficking at the endosome. TOM1 also has a predicted central coiled-coil domain. Human TOM1 shares 76% amino acid sequence identity with chicken tom1 and 89% identity with mouse Tom1. Northern blot analysis of human tissues detected a ubiquitously expressed 2.3-kb TOM1 transcript, with the highest expression in skeletal muscle, placenta, heart, and liver, and lower expression in brain, lung, kidney, and pancreas. In situ hybridization of a 17.5-day mouse embryo showed ubiquitous Tom1 expression, with the highest level in the intestines.