Terminal Uridylyl Transferase 1 (TUT1)

TUT1 encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation. CCDS Note: The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data, and by conservation data in higher primate species.The deduced 874-amino acid TUT1 protein has a calculated molecular mass of 93.4 kD. It contains an N-terminal C2H2 zinc finger RNA-binding domain, an RNA recognition motif, and a central TRF4 element that overlaps with a poly(A) polymerase (PAP)-associated domain.