Testis Expressed Protein 28 (TEX28)

TEX28 contains 5 exons and spans at least 96% of the 25.5 kb between the GCP and transketolase-2 (TKTL1) genes. It is transcribed in the orientation opposite to GCP and TKTL1.

Hanna et al. (1997) analyzed ESTs from a variety of human cDNA libraries and identified a sequence identical to intergenic regions of the red (RCP) and green (GCP) color pigment gene cluster. The EST was derived from a testis cDNA clone. The longest open reading frame encodes a polypeptide of 410 amino acids. A 1.8-kb transcript of the gene, which the authors called TEX28, was detected in testis, but not in other tissues examined.Using PCR, Chen et al. (2006) detected high expression of TEX28 in testis and marginal expression in prostate, spleen, brain, breast, pancreas, and placenta.