Testis Specific Protein 14 (TSGA14)

TSGA14 contains 11 exons and spans approximately 50 kb. The short variant is encoded by 3 exons, the first 2 exons in common with the long variant and a third exon located in intron 2 of the long variant.

TSGA14 encoding deduced proteins of 373 and 54 amino acids.Northern blot analysis detected transcripts of the longer isoform in adult testis (1.4 and 3.7 kb) and in fetal brain, lung, liver, and kidney (3.7 and 2.9 kb). A 1.1-kb transcript of the shorter isoform was weakly expressed in adult testis and fetal tissues. Using methylation analysis of a CpG island in TSGA14 intron 1 and analysis of biallelic expression of an exon 1 SNP in fetal tissues and blood lymphocytes, TSGA14 escapes genomic imprinting.