Testis Specific Y Encoded Like Protein 1 (TSPYL1)

The TSPY protein, which is encoded by a repetitive gene family on the Y chromosome, is expressed specifically in testis. As with the mouse Tspyl gene, the human TSPYL gene appears to lack introns. RT-PCR detected human TSPYL expression in the 3 tissues tested, namely liver, kidney, and smooth muscle. Northern blot analysis and RT-PCR showed ubiquitous expression of mouse Tspyl, with testis, ovary, prostate, brain, spleen, kidney, lung, heart, and liver tested. RT-PCR of embryonic mouse mRNAs from different developmental stages revealed Tspyl expression as early as 10.5 days postcoitum, the earliest stage examined.the human TSPYL gene mapped to chromosome 6. the mouse Tspyl gene mapped to chromosome 10, which shows homology of synteny with human 6q21-q23.