Tetraspanin 33 (TSPAN33)
PEN; Penumbra; Proerythroblast new membrane
The mouse Tspan33 (Penumbra) gene was cloned based on its differential expression in proerythroblasts/erythroblasts (Pasquini et al., 2003). Using the mouse Tspan33 sequence as a probe, Pasquini et al. (2003) cloned a human TSPAN33 cDNA from a bone marrow cDNA library. The deduced 283-amino acid protein shares 97% sequence identity with the mouse ortholog.
Using transfection experiments in mouse erythroleukemia (MEL) cells, Pasquini et al. (2003) found that Tspan33 exhibited growth-suppressive activity. Expression of siRNA targeted to the Tspan33 cDNA appeared to decrease the clonal growth of MEL cells.Chen et al. (2005) determined that the TSPAN33 gene contains 9 exons and spans approximately 25 kb.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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