Thrombospondin Type I Domain Containing Protein 7B (THSD7B)

THSD7B contains 17 TSP type-1 domains, The thrombospondins (TSP) are a family of multifunctional proteins. The family consists of thrombospondins 1-5 and can be divided into 2 subgroups: A, which contains TSP-1 and -2, and B, which contains TSP-3, -4 and -5.
The 2q21.1 to 22 region contains the thrombospondin type-1 domain-containing protein 7B precursor gene (THSD7B), which encodes a protein with unknown function. THSD7B is a single-pass type I membrane protein of 1608 amino acids (179402 Da), and is merely characterized as possessing a TSP1 domain. At the genome level, THSD7B is related to THSD7A and the pseudogene LAT1-3TM; so overall it does not appear as obvious candidate for cardiovascular (patho)physiology.