Thyroid Adenoma Associated Protein (THADA)

The cDNA contains repetitive elements in its 5-prime end, and the deduced protein contains 894 amino acids. RT-PCR ELISA detected high expression in liver and moderate expression in all other adult and fetal tissues examined.The full-length protein contains 1,954 amino acids and has a calculated molecular mass of 220 kD.

THADA gene contains 38 exons and spans about 365 kb. The full-length THADA protein contains an ARM repeat for protein-protein interactions. Human THADA shares 95.9%, 78.2%, and 64.9% amino acid similarity with African green monkey, mouse, and chicken Thada, respectively. The most conserved region of THADA among vertebrates corresponds to amino acids 1033 to 1415 of human THADA.