Thyroid Hormone Receptor Interactor 4 (TRIP4)

The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. They must specifically interact with a number of proteins as they progress from their initial translation and nuclear translocation to heterodimerization with retinoid X receptors (RXRs), functional interactions with other transcription factors and the basic transcriptional apparatus, and eventually, degradation.

TRIP4 interacted with rat Thrb only in the presence of thyroid hormone. It also showed a ligand-dependent interaction with RXR-alpha, but did not interact with the glucocorticoid receptor under any condition. TRIP4 contains a putative zinc finger motif with an arrangement of cysteines nearly identical to that of the zinc-binding sequence in the adenovirus E1A transactivator.