Tigger Transposable Element Derived Protein 2 (TIGD2)

TIGD2 belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known.

DNA transposons, such as Tiggers, are repetitive elements that move in the genome by excision and reintegration without an RNA intermediate. TIGD2 belongs to a family of genes derived from Tiggers.Hartz (2009) mapped the TIGD2 gene to chromosome 4q22.1 based on an alignment of the TIGD2 sequence with the genomic sequence (build 36.1).Dou et al. (2004) reported that TIGD2 contains 525 amino acids.