Trafficking Protein Particle Complex 1 (TRAPPC1)

By screening a PAC library with a cDNA clone isolated from a melanoma cell line, followed by 5-prime RACE, Chiari et al. (1999) obtained TRAPPC1, which they called MUM2. The deduced 145-amino acid protein is homologous to yeast Bet5. Northern blot analysis detected TRAPPC1 at 0.8 kb.

Chiari et al. (1999) noted that yeast Bet5 is implicated in vesicular transport of proteins from the endoplasmic reticulum to the Golgi. They found that wildtype TRAPPC1 could complement Bet5 function in yeast with a disrupted Bet5 gene. They concluded that the function of TRAPPC1 is conserved in eukaryotic cells and that it is involved in vesicular transport of proteins.