Trafficking Protein Particle Complex 2 Like Protein (TRAPPC2L)

By sequencing clones obtained from a CD34-positive hematopoietic stem/progenitor cell cDNA library, Zhang et al. (2000) cloned TRAPPC2L. The deduced protein contains 139 amino acids. TRAPPC2L was expressed in all 5 human hematopoietic cell lines examined.Zhang et al. (2000) determined that the TRAPPC2L gene contains at least 4 exons.

Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumor maintenance relies on cancer stem cells, which co-opt stem cell properties. In murine skin, follicular morphogeneis is driven by bulge stem cells that specifically express CD34.