Trafficking Protein Particle Complex 6A (TRAPPC6A)

TRAPPC6A is a subunit of the TRAPP I and II complexes. Mouse and human TRAPPC6A encode deduced 159-amino acid proteins that share 83% identity and have calculated molecular masses of 17.4 kD.

Both proteins contain 2 motifs conserved in TRAPPC6B and several yeast TRAPP subunits, including Trs33, the putative homolog of TRAPPC6A and TRAPPC6B. Northern blot analysis detected Trappc6a expression in all mouse tissues examined, with highest expression in kidney, liver, and testis. Expression of mouse Trappc6a was higher in cultured melanocytes than in kidney.The International Radiation Hybrid Mapping Consortium mapped the TRAPPC6A gene to chromosome 19.