Trafficking Protein Particle Complex 9 (TRAPPC9)

NIBP binds NIK and IKK-beta (IKBKB) and plays a role in the neuronal NF-kappa-B signaling pathway. The deduced 1,246-amino acid protein has a calculated molecular mass of 139.4 kD and shares 80 to 90% homology with the corresponding rodent sequences.

Trappc9 immunoreactivity was widespread in the cytoplasm, without specific localization to any particular organelle, and was not found in the nucleus. In 11.5-week human embryonic brain, there was higher expression in the developing cortical plate compared to the ventricular zone, indicating higher expression in postmitotic neurons than in progenitor cells.Trappc9 was found in neurons of the cerebral cortex, hippocampus, and deep gray matter.