Trans-2,3-Enoyl Coenzyme A Reductase (TECR)

Microsomal long and very long chain fatty acid elongation uses malonyl-CoA as the 2-carbon donor and consists of 4 sequential reactions. TER catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA.

The deduced 308-amino acid protein contains 5 transmembrane domains. It shares 95% amino acid identity with mouse Ter and 34% identity with yeast Tsc13. Northern blot analysis detected a 1.2-kb transcript in all human and mouse tissues examined. Epitope-tagged TER colocalized predominantly with long chain fatty acid elongase (ELOVL6) in the endoplasmic reticulum of transfected Chinese hamster ovary cells. A small amount colocalized with GM130 (GOLGA2) in the Golgi.