Transcription Factor 7 Like Protein 1 (TCF7L1)

TCF7L1 was occasionally upregulated in primary gastric cancer compared with normal gastric mucosa.TCF/LEF transcription factors, such as TCF7L1, are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta (TGFB1) signaling pathway.

The deduced 588-amino acid protein contains a beta-catenin (CTNNB1)-binding domain at its N terminus, followed by an HMG box, a nuclear translocation signal, and 2 putative CTBP-binding sites at its C terminus. TCF7L1 shares 58% amino acid identity with TCF7L2, its closest homolog among human TCF proteins. Northern blot analysis detected a 3.0-kb TCF7L1 transcript in human stomach and in some human gastric cancer cell lines.