Transcription Factor 7 Like Protein 2 (TCF7L2)

TCF4; HMG box transcription factor 4
Transcription Factor 7 Like Protein 2 (TCF7L2)
TCF7L2 encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes.TCF7L1 and TCF7L2 were not expressed in cells of the lymphoid lineage. The deduced amino acid sequences of the HMG boxes of TCF7L1, TCF7L2, and TCF7 show striking homology. That gene activation by the beta-catenin/TCF4 complex is a critical event in cancer development is indicated by the fact that a subset of colorectal cancers that lack somatic mutations in APC show somatic mutations in the beta-catenin gene. These mutations are presumed to render beta-catenin insensitive to regulation by APC and GSK3B.
Organism species: Homo sapiens (Human)
  • Protein RPP601Hu01Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • AntibodyPAP601Hu01Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • AntibodyMAP601Hu21Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • Assay KitSEP601HuELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • Assay KitSCP601HuCLIA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPP601Mu01Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • AntibodyPAP601Mu01Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • AntibodyMAP601Mu21Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • Assay KitSEP601MuELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • Assay KitSCP601MuCLIA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPP601Ra01Recombinant Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • AntibodyPAP601Ra01Polyclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • AntibodyMAP601Ra21Monoclonal Antibody to Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • Assay KitSEP601RaELISA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
  • Assay KitSCP601RaCLIA Kit for Transcription Factor 7 Like Protein 2 (TCF7L2)Customize
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