Transcriptional Adaptor 1 (TADA1)

TADA1L is a protein subunit of the human STAGA complex (SPT3/TAF9/GCN5 acetyltransferase complex), which is a chromatin-modifying multiprotein complex.By affinity purification of the human STAGA complex, followed by database analysis, Martinez et al. (2001) identified TADA1L, which they called STAF42. The deduced 335-amino acid protein has a calculated molecular mass of 47 kD and shares 19% amino acid identity with S. cerevisiae Hfi1/Ada1. TADA1L contains a histone H2A-like domain that is shared by yeast Hfi1 and conserved in human TAF4.STAGA complex is an acyl-CoA-dependent transcriptional coactivator on a chromatin-assembled template in vitro, and they suggested that STAGA may play a role in chromatin activation, transcriptional regulation, and DNA damage repair.