Transcriptional Adaptor 2 Alpha (TADA2a)

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. TADA2A is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.TADA2L gene contains 17 principal exons and is oriented in a head-to-head fashion with the ACACA gene. The intergenic region, which is embedded within a CpG island, contains 2 promoters and exon 1 of the TADA2L gene and the first promoter and exon 1 of the ACACA gene. The shared promoter contains an AP2 motif, but no TATA or CCAAT boxes.