Home  |   About us
ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Transducin Like Enhancer Of Split 1 (TLE1)
ESG; ESG1; GRG1; Enhancer Of Split Groucho 1
TLE1 binds to the Runt domain and the C terminus of AML1 (RUNX1), but not to CBFB, mainly through the SP domain but also through the WD-40 domain of TLE1. Binding of TLE1 to the C terminus of RUNX1 inhibits RUNX1-induced transactivation of the CSF1 receptor (CSF1R).
Northern blot analysis detected TLE1 transcripts of 4.4 and 2.6 kb. Expression was highest in skeletal muscle and liver, moderate in placenta, heart, kidney, and spleen, and weak in all other tissues examined, including brain.Mutation analysis showed that both the AF1 and AF2 domains of Esrrg2 were required for TLE1-dependent transactivation. The WD40 domain of TLE1 was required for interaction with Esrrg2, and the GP and Q domains of TLE1 were important for Esrrg2 coactivation.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPM371Hu01 Recombinant Transducin Like Enhancer Of Split 1 (TLE1) Customize
Antibodies PAM371Hu01 Polyclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Customize
MAM371Hu21 Monoclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Customize
Assay Kits SEM371Hu ELISA Kit for Transducin Like Enhancer Of Split 1 (TLE1) Customize
SCM371Hu CLIA Kit for Transducin Like Enhancer Of Split 1 (TLE1) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPM371Mu01 Recombinant Transducin Like Enhancer Of Split 1 (TLE1) Customize
Antibodies PAM371Mu01 Polyclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Customize
MAM371Mu21 Monoclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Customize
Assay Kits SEM371Mu ELISA Kit for Transducin Like Enhancer Of Split 1 (TLE1) Customize
SCM371Mu CLIA Kit for Transducin Like Enhancer Of Split 1 (TLE1) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPM371Ra01 Recombinant Transducin Like Enhancer Of Split 1 (TLE1) Customize
Antibodies PAM371Ra01 Polyclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Customize
MAM371Ra21 Monoclonal Antibody to Transducin Like Enhancer Of Split 1 (TLE1) Customize
Assay Kits SEM371Ra ELISA Kit for Transducin Like Enhancer Of Split 1 (TLE1) Customize
SCM371Ra CLIA Kit for Transducin Like Enhancer Of Split 1 (TLE1) Customize