Transducin Like Enhancer Of Split 2 (TLE2)

The TLE genes are human homologs of the Drosophila 'groucho' gene and their products belong to this pathway. Analysis of mutant alleles of members of the Notch cascade showed that Notch signaling extends the differentiation-competent state of developmentally immature precursor cells, thereby preventing or delaying their differentiation until the correct morphogenetic signals become available . A number of pathologies resulting from incomplete cellular differentiation due to this general inhibitory action during cell determination were shown to be the result of alterations in Notch signaling, including both lymphoblastic and epithelial neoplasms. TLE1 , TLE2, and TLE3 are coexpressed in a number of epithelial tissues. Moreover, they showed that the expression is elevated in cervical squamous metaplasias and carcinomas.