Transducin Like Enhancer Of Split 3 (TLE3)

Stifani et al. (1992) described human homologs of Drosophila groucho protein; these were designated TLE for 'transducin-like enhancer of split.' By Southern analysis of genomic DNA from human/Chinese hamster somatic hybrid cell lines, Miyasaka et al. (1993) mapped the TLE3 gene to chromosome 15. Mouse Esg (for 'enhancer of split groucho'), the homolog of human TLE3, was found to be represented by transcripts of 3.3 kb and 4.0 kb only in testis. Richard et al. (1994) presented an integrated physical, expression, and genetic map of human chromosome 15. By PCR analysis, they concluded that the TLE3 gene lies in their region II: 15q14-q15.1. On the other hand, by fluorescence in situ hybridization, which may be more precise, Liu et al. (1996) mapped TLE3 to 15q22.