Transient Receptor Potential Cation Channel Subfamily C, Member 5 (TRPC5)

The predicted 973-amino acid TRPC5 protein has a calculated molecular mass of 111.5 kD. It contains the characteristic 8 predicted transmembrane domains (TM1 through TM8), including a pore region (TM7) between TM6 and TM8. The N-terminal cytoplasmic region has 2 putative ankyrin motifs and 2 conserved potential cAMP- and cGMP-dependent protein kinase phosphorylation sites. The C-terminal cytoplasmic region has another potential cAMP-and cGMP-dependent protein kinase phosphorylation site and a VTRRL motif, which resembles the PDZ domain interaction site of other ion channels. Human TRPC5 shares 97% amino acid identity with mouse Trp5 and 99% identity with a rabbit TRP, Cce2. Together with bovine Trp4, these proteins form a subbranch of the TRP superfamily.