Transient Receptor Potential Cation Channel Subfamily C, Member 7 (TRPC7)

TRPC7 belongs to the transient receptor family. STrpC subfamily.TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. Structurally, this family shares a number of similar characteristics.

At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble.In general, TRPC channels can be activated by phospholipase C stimulation, with some members also activated by diacylglycerol.