Transient Receptor Potential Cation Channel Subfamily V, Member 5 (TRPV5)

TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca²⁺. Genetic deletion of TRPV5 in mice leads to Ca²⁺ loss in the urine, and consquentual hyperparathyroidism, and bone loss..

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.