Transmembrane 6 Superfamily, Member 1 (TM6SF1)

By searching an EST database to identify genes on chromosome 15q24-q26, followed by RACE on a fetal brain cDNA library, Carim-Todd et al. (2000) obtained a cDNA encoding TM6SF1. They also identified a paralog, TM6SF2, on chromosome 19p12. The deduced 370-amino acid TM6SF1 protein has 6 transmembrane domains. Northern blot analysis revealed expression of a 1.4-kb TM6SF1 transcript in spleen, testis, and peripheral blood leukocytes.

By genomic sequence analysis, Carim-Todd et al. (2000) determined that the TM6SF1 gene contains 10 exons.By genomic sequence analysis, Carim-Todd et al. (2000) mapped the TM6SF1 gene to chromosome 15q24-q26.