Transmembrane 6 Superfamily, Member 2 (TM6SF2)

By searching an EST database using TM6SF1 as the probe, Carim-Todd et al. (2000) obtained a cDNA encoding TM6SF2. The deduced 351-amino acid protein, which is 52% identical to TM6SF1, has 6 transmembrane domains. By screening for cDNAs with the potential to encode large proteins in brain, Nagase et al. (2001) identified a cDNA encoding TM6SF2, which they termed KIAA1926. KIAA1926 encodes a predicted 412-amino acid link protein, and the authors noted the existence of shorter isoforms. RT-PCR analysis detected high-level expression of KIAA1926 in adult and fetal brain, moderate expression in ovary, and low or undetectable expression in other tissues. Within brain, expression was highest in amygdala and thalamus, with high levels also detected in other brain regions.