Transmembrane Emp24 Protein Transport Domain Containing Protein 3 (TMED3)

TMED3, Belongs to the EMP24/GP25L family. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles.

Members of the yeast p24 family, including Emp24p and Erv25p, form a heteromeric complex required for the efficient transport of selected proteins from the endoplasmic reticulum (ER) to the Golgi apparatus. The specific functions and sites of action of this complex are unknown. Emp24p is directly required for efficient packaging of a lumenal cargo protein, Gas1p, into ER-derived vesicles. Emp24p and Erv25p can be directly cross-linked to Gas1p in ER-derived vesicles. Gap1p, which was not affected by emp24 mutation, was not cross-linked. Emp24 complex acts as a cargo receptor in vesicle biogenesis from the ER.