Transmembrane Protease, Serine 11D (TMPRSS11D)

TMPRSS11D encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. The protein contains a single hydrophobic region near the N terminus which is thought to correspond to a transmembrane domain. The predicted protein is a type II integral membrane protein synthesized as a membrane-bound precursor protein that is translocated to the cell surface, processed to a soluble form, and released.