Transmembrane Protease, Serine 11E (TMPRSS11E)

Human TMPRSS11E encodes a 422-amino acid protein, which contains a short N-terminal cytoplasmic domain, a transmembrane domain, a single SEA domain, and a C-terminal serine protease domain. RT-PCR analysis showed strong expression of Tmprss11e in mouse keratinocytes, and dot blot analysis showed strong expression of Tmprss11e in salivary glands and epididymis. Studies of mouse Tmprss11e showed that it was N-glycosylated, and expression of recombinant Tmprss11e in insect cells showed that Tmprss11e was synthesized as a zymogen that could be activated by exposure to trypsin.The deduced 422-amino acid protein has a short N-terminal region followed by a transmembrane domain and an extracellular C-terminal catalytic domain containing the conserved catalytic triad and catalytic cleavage site.