Transmembrane Protein 106A (TMEM106A)

The TMEM106A protein has a molecular weight of 28.9 kdal. It has 262 amino acids, 240 of which are in the domain of function. The protein has a transmembrane region. There is evidence for a secondary transmembrane region in humans but this region is not conserved in related orthologs. The protein does not contain a peptide signal protein. The protein structure contains a similar proportion of alpha-helix and beta-strand secondary structures. TMEM106A is expressed in several human tissues. The tissues with highest expression are uterus, kidneys, small intestine, and stomach. EST profiles for orthologs show expression is conserved with greatest expression in kidneys and lesser expression in several other areas. Some tissues never show expression including: muscle, adipose tissue, and bone.