Transmembrane Protein 11 (TMEM11)

A transmembrane protein is a polytopic protein that spans the entire biological membrane. Transmembrane proteins aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them (beta-barrels) can be also extracted using denaturing agents.

RASSF1A, encodes a pro-apoptotic tumour suppressor and its loss is associated with many cancers including MM. At least two more genes from the same area, TUSC2 and TMEM11, may also be associated with cancer. Forced expression of TUSC2 resulted in tumour growth suppression. It was found that expression of TUSC2 could stimulates p53-regulated apoptosis, and thus both genes might be important TSGs.