Transmembrane Protein 115 (TMEM115)

PL6 is an unlikely candidate tumor suppressor gene.is an unlikely candidate tumor suppressor gene.The deduced 351-amino acid conserved integral protein is 92% identical to the mouse protein and contains 6 to 8 transmembrane helices.

The cytoplasmic portions of PL6 contain an OMPdecase domain, which is possibly involved in protein-protein interactions, and a bipartite nuclear localization signal. Northern blot analysis revealed wide expression of a 2.2-kb transcript that was strongest in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain. PL6 was highly expressed in most lung cancer cell lines. No mutations were detected in any of the lung cancer cell lines tested.