Transmembrane Protein 123 (TMEM123)

TMEM123 encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.The cDNA encodes a deduced 189-amino acid type I transmembrane protein. Its extracellular domain contains many O-linked and 7 N-linked glycosylation sites that define it as a member of the mucin family.