Transmembrane Protein 126B (TMEM126B)

TMEM126B is a transmembrane protein with unknown function. The Tmem126b gene is conserved in mammals. TMEM126B was first discovered in a study of protein expression in tissues of the hypothalamus-pituitary-adrenal axis using full cDNA cloning. It has since been detected in other tissues.

TMEM126B is expressed in most tissue types, with the notable exceptions of adipose tissue, ear tissue, the larynx, lymph tissue, nerve tissue, pituitary gland, spleen, thymus, thyroid, trachea, and umbilical chord. It also appears to be highly expressed in parathyroid, bone marrow, and urinary bladder tissue. There is also evidence that one of the isoforms of TMEM126B is expressed in the cell membrane of memory B cells of the adaptive immune system.