Transmembrane Protein 127 (TMEM127)

The TMEM127 protein contains 238 amino acids with 3 predicted transmembrane domains and shares 98.7% and 85.2% amino acid identity with mouse and zebrafish protein, respectively. Northern blot analysis of human tissues showed most abundant expression of 4.2-, 3.8-, and 3.1-kb transcripts in heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, small intestine, and colon.

TMEM127 expression was also found in a variety of epithelial cancer cell lines, including those derived from brain, breast, colon, prostate, and liver. Mouse Tmem127 showed ubiquitous expression in all mouse tissues examined at 1 month and 5 months of age. Immunoblot assay detected TMEM127 as a 26-kD band in transfected HEK293 cells.