Transmembrane Protein 176A (TMEM176A)

By serologic analysis of recombinant cDNA expression libraries (SEREX) from 4 hepatocellular carcinoma patients, Wang et al. (2002) cloned HCA112. The deduced protein contains 235 amino acids. RT-PCR detected HCA112 expression in human kidney, lung, and pancreas, but not in any other tissue examined.

Nakajima et al. (2002) cloned the mouse homolog of HCA112, Gs188. The deduced 244-amino acid protein has a calculated molecular mass of 26.6 kD and contains 4 putative hydrophobic domains. Northern blot analysis detected Gs188 expression in mouse kidney, lung, and spleen; little to no expression was detected in other tissues examined.