Transmembrane Protein 178 (TMEM178)

Transmembrane Protein 178 (TMEM178)
TMEM178 is a 297 amino acid protein that is localized to the membrane. TMEM178 is a multi-pass membrane protein with identified homologs in mouse, rat and Xenopus. Human TMEM178 contains a 25 amino acid signal peptide and a mature chain that spans amino acids 26 to 297. Two isoforms of TMEM178 exist as a result of alternative splicing events. TMEM178 is encoded by a gene that maps to chromosome 2. The second largest human chromosome, 2 consists of 237 million bases encoding over 1,400 genes and making up approximately 8% of the human genome. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)