Transmembrane Protein 179 (TMEM179)

TMEM179 is located on human 14q32.33 approximately 1 Mb upstream from the immunoglobulin heavy chain (IGH) region, which has been involved in translocations in multiple myelomas and plasma cell leukemias. Human 14q32.33 has also been identified as an EB. The localization of A8 adjacent to the 1q EB clones and the activity of IGH in human cancer compelled a closer examination of the IGH orthologous locus in human with respect to conserved features.

Interestingly, the EU BAC A8 carries a predicted gene with high nucleotide homology (83.8% identity) to the human gene Transmembrane protein 179 (TMEM179) . Sequence alignments using MultiPipMaker with repeats masked were performed comparing each tammar EB clone (I6, G7 and B9) with clone sequences used in the assembly of human chromosome 14q32.33, spanning IGHv to TMEM179.