Transmembrane Protein, Adipocyte Associated 1 (TPRA1)

The deduced 298-amino acid protein has a calculated molecular mass of 33 kD and contains 7 putative transmembrane domains. Tpra40 can be posttranslationally modified by N-glycosylation, phosphorylation, and myristoylation. Northern blot analysis of mouse tissues detected a major 2.0-kb transcript expressed at highest levels in heart, brain, lung, liver, and kidney. Intermediate expression was detected in spleen and skeletal muscle, but expression was not detected in testis. A minor 6.0-kb transcript was also detected in some tissues. Northern blot analysis of human tissues detected a 2.0-kb transcript expressed at highest levels in heart, placenta, and kidney. Moderate expression was detected in liver, skeletal muscle, and pancreas, with lowest levels in brain and lung.