Tripartite Motif Containing Protein 10 (TRIM10)

TRIM10 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms.Sequence analysis predicted that the 481-amino acid protein contains a RING finger-B box domain encoded by exon 1, a coiled-coil domain encoded by exons 2 through 6, and a B30.2 domain encoded by exon 7.Northern blot analysis of mouse tissue detected a 2.3-kb transcript only in spleen and bone marrow erythroid cells. In embryonic mice, expression was detected on day 11.5 at the beginning of erythropoiesis.