Tripartite Motif Containing Protein 11 (TRIM11)

TRIM11, a peptide with neuroprotective activities against Alzheimer disease-associated insults. Both the coiled-coil domain and the C-terminal RFP-like domain of TRIM11 were necessary for interaction with HN. Coexpression of HN and TRIM11 diminished intracellular levels of HN. The authors noted that the TRIM11 RING finger domain acts as a putative E3 ubiquitin ligase, and suggested that TRIM11 regulates intracellular HN levels through ubiquitin-mediated protein degradation pathways.The deduced protein contains an N-terminal RING domain, a type-2 B-box domain, a coiled-coil region, and 3 C-terminal RFP (B30.2) -like domains. Northern blot analysis of adult human tissues indicated ubiquitous expression, and in situ hybridization of mouse embryos showed expression in CNS, thymus, kidney, and gut.