Tripartite Motif Containing Protein 27 (TRIM27)

TRIM27 encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.Yeast 2-hybrid assays revealed that the coiled-coil domain of RFP associated with the EPcA domain and the C-terminal region of EPC. Both proteins coprecipitated from lysates of human cells and mostly colocalized in the nucleus.