Tripartite Motif Containing Protein 46 (TRIM46)

Vos et al. (1995) identified a gene, designated gene Y (GENEY) by them, located downstream of the MUC1 gene in both human and mouse. The 2 genes are part of a cluster of genes on human 1q21 and mouse chromosome 3 (E3-F1). In both species, the genes are transcribed in opposite directions, i.e., convergently. The GENEY transcript of about 8 kb was expressed in many tissues. By searching for sequences encoding RBCC (N-terminal RING finger/B-box/coiled-coil) proteins, Short and Cox (2006) identified TRIM46, which they called TRIFIC. The deduced protein contains an N-terminal RING finger domain, 2 B-boxes, a coiled-coil region, a COS box, an FN3 domain, and a B30.2 domain. Fluorescence-tagged TRIM46 appeared to associated with microtubules in transfected COS-1 cells.