Tripartite Motif Containing Protein 6 (TRIM6)

TRIM6 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.Fluorescence-tagged TRIM6 showed punctate cytoplasmic expression in transfected osteocarcinoma and HeLa cells. Disruption of the RING domain, the B-box domain, or the coiled-coil region caused redistribution and more diffuse staining of cytoplasmic and nuclear structures.