Tripartite Motif Containing Protein 32 (TRIM32)

TRIM32 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. HT2A contains an N-terminal C3HC4 zinc finger motif, indicating that it is a member of the ring finger family which includes transcription factors, nucleic acid binding proteins, and oncogenes. HT2A is most similar to the ring finger subfamily that includes RFP, PML, T18, RPT1, and Ro autoantigen since it contains a cysteine/histidine cluster and a heptad repeat of hydrophobic residues that is predicted to form a coiled-coil structure.